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Applied and Environmental Microbiology, July 2009, p. 4919-4922, Vol. 75, No. 14
0099-2240/09/$08.00+0     doi:10.1128/AEM.00681-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Antibiotic Overproduction by rpsL and rsmG Mutants of Various Actinomycetes{triangledown} ,{dagger}

Yukinori Tanaka,1,2 Mamoru Komatsu,3 Susumu Okamoto,1 Shinji Tokuyama,2 Akira Kaji,4 Haruo Ikeda,3 and Kozo Ochi1*

National Food Research Institute, Tsukuba, Ibaraki 305-8642, Japan,1 Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan,2 Kitasato Institute for Life Sciences, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan,3 School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 191044

Received 24 March 2009/ Accepted 11 May 2009

Certain streptomycin resistance mutations (i.e., rpsL and rsmG) result in the overproduction of antibiotics in various actinomycetes. Moreover, rpsL rsmG double-mutant strains show a further increase in antibiotic production. rpsL but not rsmG mutations result in a marked enhancement of oligomycin production in Streptomyces avermitilis and erythromycin production in Saccharopolyspora erythraea, accompanied by increased transcription of a key developmental regulator gene, bldD, in the latter organism.

* Corresponding author. Mailing address: National Food Research Institute, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan. Phone: 81-29-838-8125. Fax: 81-29-838-7996. E-mail: kochi{at}affrc.go.jp

{triangledown} Published ahead of print on 15 May 2009.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

Applied and Environmental Microbiology, July 2009, p. 4919-4922, Vol. 75, No. 14
0099-2240/09/$08.00+0     doi:10.1128/AEM.00681-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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