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 Previous Article

Applied and Environmental Microbiology, July 2009, p. 4923-4925, Vol. 75, No. 14
0099-2240/09/$08.00+0     doi:10.1128/AEM.00363-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Long-Term Survival of Salmonella enterica Serovar Typhimurium Reveals an Infectious State That Is Underrepresented on Laboratory Media Containing Bile Salts{triangledown}

Dmitry Apel,1,{dagger} Aaron P. White,1,{dagger} Guntram A. Grassl,3 B. Brett Finlay,3,4 and Michael G. Surette1,2*

Department of Microbiology and Infectious Diseases,1 Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada T2N 4N1,2 Michael Smith Laboratories,3 Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z44

Received 14 February 2009/ Accepted 24 May 2009

Cells in desiccated Salmonella enterica serovar Typhimurium rdar (red, dry, and rough) morphotype colonies were examined for culturability and infectivity after 30 months. Culturability decreased only 10-fold; however, cells were underrepresented on Salmonella selective media containing bile salts. These cells were mildly attenuated compared to the infectivity of freshly grown cells but still able to cause systemic infections in mice.

* Corresponding author. Mailing address: Department of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, AB T2N 4N1, Canada. Phone: (403) 220-2744. Fax: (403) 270-2772. E-mail: surette{at}ucalgary.ca

{triangledown} Published ahead of print on 29 May 2009.

{dagger} These authors contributed equally to this work.

Applied and Environmental Microbiology, July 2009, p. 4923-4925, Vol. 75, No. 14
0099-2240/09/$08.00+0     doi:10.1128/AEM.00363-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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