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Applied and Environmental Microbiology, August 2009, p. 5373-5379, Vol. 75, No. 16
0099-2240/09/$08.00+0     doi:10.1128/AEM.00724-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Synthetic Ultrashort Cationic Lipopeptides Induce Systemic Plant Defense Responses against Bacterial and Fungal Pathogens {triangledown}

Yariv Brotman,1 Arik Makovitzki,2 Yechiel Shai,2 Ilan Chet,1 and Ada Viterbo1*

Department of Plant Pathology and Microbiology, The Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel,1 Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel2

Received 29 March 2009/ Accepted 16 June 2009

A new family of synthetic, membrane-active, ultrashort lipopeptides composed of only four amino acids linked to fatty acids was tested for the ability to induce systemic resistance and defense responses in plants. We found that two peptides wherein the third residue is a D-enantiomer (italic), C16-KKKK and C16-KLLK, can induce medium alkalinization of tobacco suspension-cultured cells and expression of defense-related genes in cucumber and Arabidopsis seedlings. Moreover, these compounds can prime systemic induction of antimicrobial compounds in cucumber leaves similarly to the plant-beneficial fungus Trichoderma asperellum T203 and provide systemic protection against the phytopathogens Botrytis cinerea B05, Pseudomonas syringae pv. lachrimans, and P. syringae pv. tomato DC3000. Thus, short cationic lipopeptides are a new category of compounds with potentially high utility in the induction of systemic resistance in plants.

* Corresponding author. Mailing address: Department of Plant Pathology and Microbiology, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel. Phone: 972-8-9489985. Fax: 972-8-9468785. E-mail: viterbo{at}agri.huji.ac.il

{triangledown} Published ahead of print on 19 June 2009.

Applied and Environmental Microbiology, August 2009, p. 5373-5379, Vol. 75, No. 16
0099-2240/09/$08.00+0     doi:10.1128/AEM.00724-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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