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Applied and Environmental Microbiology, September 2009, p. 5727-5728, Vol. 75, No. 17
0099-2240/09/$08.00+0     doi:10.1128/AEM.02715-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Carbohydrate Metabolism Differences between Subgroup A1 and B2 Strains of Bacillus anthracis as Assessed by Comparative Genomics and Functional Genetics{triangledown}

Patricia Sylvestre,1 Mary Moya,1 Michel Haustant,1 Josée Vaissaire,2 and Michèle Mock1*

Institut Pasteur, Unité Toxines et Pathogénie Bactériennes (URA 2172, CNRS), Paris, France,1 Equipe Charbon AFSSA/LERPAZ, Maisons-Alfort, France2

Received 27 November 2008/ Accepted 19 June 2009

In France, Bacillus anthracis subgroup B2 strains do not metabolize starch or glycogen but can use gluconate, whereas subgroup A1 strains show the inverse pattern. Functional genetic analysis revealed that mutations in the amyS and gntK genes encoding an alpha-amylase and a gluconate kinase, respectively, were responsible for these phenotypes.

* Corresponding author. Mailing address: Institut Pasteur, Unité Toxine et Pathogénie Bactériennes, 28 rue du Dr. Roux, 75724 Paris cédex 15, France. Phone: 33 1 45 68 83 12. Fax: 33 1 45 68 89 54. E-mail: mmock{at}pasteur.fr

{triangledown} Published ahead of print on 6 July 2009.

Applied and Environmental Microbiology, September 2009, p. 5727-5728, Vol. 75, No. 17
0099-2240/09/$08.00+0     doi:10.1128/AEM.02715-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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