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Applied and Environmental Microbiology, September 2009, p. 5991-5995, Vol. 75, No. 18
0099-2240/09/$08.00+0     doi:10.1128/AEM.01170-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Interactions of Typical and Atypical Enteropathogenic Escherichia coli Strains with the Calf Intestinal Mucosa Ex Vivo{triangledown}

Francis Girard,1 Francis Dziva,2 Mark P. Stevens,2 and Gad Frankel1*

Centre for Molecular Microbiology and Infection, Division of Cell & Molecular Biology, Imperial College London, London,1 Enteric Bacterial Pathogens Group, Division of Microbiology, Institute for Animal Health, Compton, Berkshire, United Kingdom2

Received 20 May 2009/ Accepted 20 July 2009

Enteropathogenic Escherichia coli (EPEC) can be found in healthy and diarrheic cattle; however, little is known about the role of attaching and effacing (A/E) lesion formation in colonization of bovine intestinal mucosa by such strains. We show that typical and atypical EPEC induce A/E lesions on calf intestinal explants independently of Tir tyrosine phosphorylation and TccP. Our data support the existence of conserved Tir- and TccP-independent mechanisms of A/E lesion formation in a range of hosts and reinforce the zoonotic potential of EPEC in cattle.

* Corresponding author. Mailing address: Centre for Molecular Microbiology and Infection, Division of Cell & Molecular Biology, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom. Phone: 44 020 2594 525. Fax: 44 020 5794 3069. E-mail: g.frankel{at}imperial.ac.uk

{triangledown} Published ahead of print on 24 July 2009.

Applied and Environmental Microbiology, September 2009, p. 5991-5995, Vol. 75, No. 18
0099-2240/09/$08.00+0     doi:10.1128/AEM.01170-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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