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Applied and Environmental Microbiology, September 2009, p. 6013-6016, Vol. 75, No. 18
0099-2240/09/$08.00+0     doi:10.1128/AEM.00495-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Role of Transporter Proteins in Bile Tolerance of Lactobacillus acidophilus{triangledown} ,{dagger}

Erika A. Pfeiler and Todd R. Klaenhammer*

Genomic Sciences Graduate Program; Department of Food, Bioprocessing, & Nutrition Sciences; and Southeast Dairy Foods Research Center, North Carolina State University, Raleigh, North Carolina 27695

Received 27 February 2009/ Accepted 18 July 2009

Lactobacillus acidophilus NCFM derivatives containing deletion mutations in the transporter genes LBA0552, LBA1429, LBA1446, and LBA1679 exhibited increased sensitivity to bile. These strains showed unique patterns of sensitivity to a variety of inhibitory compounds, as well as differential accumulations of ciprofloxacin and taurocholate.

* Corresponding author. Mailing address: Dept. of Food Science, North Carolina State University, Raleigh, NC 27695. Phone: (919) 515-2972. Fax: (919) 513-0014. E-mail: trk{at}unity.ncsu.edu

{triangledown} Published ahead of print on 24 July 2009.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

Applied and Environmental Microbiology, September 2009, p. 6013-6016, Vol. 75, No. 18
0099-2240/09/$08.00+0     doi:10.1128/AEM.00495-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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