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Applied and Environmental Microbiology, October 2009, p. 6402-6405, Vol. 75, No. 19
0099-2240/09/$08.00+0     doi:10.1128/AEM.00952-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Little Heterogeneity among Genes Encoding Heat-Labile and Heat-Stable Toxins of Enterotoxigenic Escherichia coli Strains Isolated from Diarrheal Pigs{triangledown}

Chengxian Zhang, Dana Rausch, and Weiping Zhang*

The Center for Infectious Disease Research & Vaccinology/Department of Veterinary Science, South Dakota State University, Brookings, South Dakota

Received 27 April 2009/ Accepted 4 August 2009

To examine whether the heat-labile enterotoxin gene in porcine enterotoxigenic Escherichia coli (ETEC) strains is as divergent as in human ETEC strains, we sequenced the heat-labile and heat-stable toxin genes from 52 and 33 porcine ETEC strains, respectively. We found that the STa gene is identical, that the LT gene has only two mutations in 4 (of 52) strains, and that both mutations cause a reduction in GM1 binding and toxicity.

* Corresponding author. Mailing address: The Center for Infectious Disease Research & Vaccinology, South Dakota State University, Box 2175, North Campus Drive, Brookings, SD 57007. Phone: (605) 688-4317. Fax: (605) 688-6003. E-mail: weiping.zhang{at}sdstate.edu

{triangledown} Published ahead of print on 14 August 2009.

Applied and Environmental Microbiology, October 2009, p. 6402-6405, Vol. 75, No. 19
0099-2240/09/$08.00+0     doi:10.1128/AEM.00952-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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