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Applied and Environmental Microbiology, November 2009, p. 6910-6912, Vol. 75, No. 21
0099-2240/09/$08.00+0     doi:10.1128/AEM.01211-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Small-Colony Variant Selection as a Survival Strategy for Staphylococcus aureus in the Presence of Pseudomonas aeruginosa{triangledown}

Lalitha Biswas, Raja Biswas, Martin Schlag, Ralph Bertram, and Friedrich Götz*

Institute of Microbial Genetics, University of Tübingen, 72076 Tübingen, Germany

Received 27 May 2009/ Accepted 24 August 2009

Previously it has been demonstrated that Staphylococcus aureus is sensitive toward Pseudomonas-secreted exotoxins, which preferentially target the electron transport chain in staphylococci. Here it is shown that a subpopulation of S. aureus survives these respiratory toxins of Pseudomonas aeruginosa by selection of the small-colony variant (SCV) phenotype. Purified pyocyanin alone causes the same effect. A hemB mutant of S. aureus survives cocultivation with P. aeruginosa without a decrease in CFU.

* Corresponding author. Mailing address: Mikrobielle Genetik, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany. Phone: (49) 7071 29746-36. Fax: (49) 7071 295039. E-mail: friedrich.goetz{at}uni-tuebingen.de

{triangledown} Published ahead of print on 28 August 2009.

Applied and Environmental Microbiology, November 2009, p. 6910-6912, Vol. 75, No. 21
0099-2240/09/$08.00+0     doi:10.1128/AEM.01211-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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