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Applied and Environmental Microbiology, February 2009, p. 848-852, Vol. 75, No. 3
0099-2240/09/$08.00+0     doi:10.1128/AEM.01595-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Antibacterial Effects of Grape Extracts on Helicobacter pylori{triangledown}

Joseph C. Brown,1 Guohui Huang,1 Vivian Haley-Zitlin,2 and Xiuping Jiang2*

Department of Biological Sciences,1 Department of Food Science & Human Nutrition, Clemson University, Clemson, South Carolina2

Received 11 July 2008/ Accepted 23 November 2008

Anti-Helicobacter pylori activities were determined by agar dilution, confocal laser scanning microscopy, and cell proliferation assays following treatment with various grape extracts. Muscadine grape skin possessed the strongest activity, followed by grape synergy (skin and seed) and seed, suggesting that higher phenolic levels do not necessarily determine overall anti-H. pylori efficacy.

* Corresponding author. Mailing address: 217 P&A Bldg., Department of Food Science & Human Nutrition, Clemson University, Clemson, SC 29634. Phone: (864) 656-6932. Fax: (864) 656-0331. E-mail: xiuping{at}clemson.edu

{triangledown} Published ahead of print on 1 December 2008.

Applied and Environmental Microbiology, February 2009, p. 848-852, Vol. 75, No. 3
0099-2240/09/$08.00+0     doi:10.1128/AEM.01595-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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