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Applied and Environmental Microbiology, February 2009, p. 1011-1020, Vol. 75, No. 4
0099-2240/09/$08.00+0     doi:10.1128/AEM.02187-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Poultry-Associated Salmonella enterica subsp. enterica Serovar 4,12:d:– Reveals High Clonality and a Distinct Pathogenicity Gene Repertoire {triangledown} ,{dagger}

Stephan Huehn, Cornelia Bunge, Ernst Junker, Reiner Helmuth, and Burkhard Malorny*

Federal Institute for Risk Assessment, Diedersdorfer Weg 1, D-12277 Berlin, Germany

Received 22 September 2008/ Accepted 17 December 2008

A European baseline survey during the years 2005 and 2006 has revealed that the monophasic Salmonella enterica subsp. enterica serovar 4,12:d:– was, with a prevalence of 23.6%, the most frequently isolated serovar in German broiler flocks. In Denmark and the United Kingdom, its serovar prevalences were 15.15% and 2.8%, respectively. Although poultry is a major source of human salmonellosis, serovar 4,12:d:– is rarely isolated in humans (approximately 0.09% per year). Molecular typing studies using pulsed-field gel electrophoresis and DNA microarray analysis show that the serovar is highly clonal and lacks genes with known contributions to pathogenicity. In contrast to other poultry-associated serovars, all strains were susceptible to 17 antimicrobial agents tested and did not encode any resistance determinant. Furthermore, serovar 4,12:d:– lacked the genes involved in galactonate metabolism and in the glycolysis and glyconeogenesis important for energy production in the cells. The conclusion of the study is that serovar 4,12:d:– seems to be primarily adapted to broilers and therefore causes only rare infections in humans.

* Corresponding author. Mailing address: Bundesinstitut für Risikobewertung, National Salmonella Reference Laboratory, Diedersdorfer Weg 1, D-12277 Berlin, Germany. Phone: (49 30) 8412 2237. Fax: (49 30) 8412 2064. E-mail: burkhard.malorny{at}bfr.bund.de

{triangledown} Published ahead of print on 29 December 2008.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

Applied and Environmental Microbiology, February 2009, p. 1011-1020, Vol. 75, No. 4
0099-2240/09/$08.00+0     doi:10.1128/AEM.02187-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Chia, T. W. R., Fegan, N., Dykes, G. A., Huehn, S., Bunge, C., Junker, E., Helmuth, R., Malorny, B. (2009). Potential Role for the 4,12 Antigen in the Prevalence of Clonal Salmonella Serovars in Poultry. Appl. Environ. Microbiol. 75: 3377-3378 [Full Text]  


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