This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blombach, B.
Right arrow Articles by Eikmanns, B. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blombach, B.
Right arrow Articles by Eikmanns, B. J.
Agricola
Right arrow Articles by Blombach, B.
Right arrow Articles by Eikmanns, B. J.

 Previous Article  |  Next Article 

Applied and Environmental Microbiology, February 2009, p. 1197-1200, Vol. 75, No. 4
0099-2240/09/$08.00+0     doi:10.1128/AEM.02351-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

L-Valine Production during Growth of Pyruvate Dehydrogenase Complex- Deficient Corynebacterium glutamicum in the Presence of Ethanol or by Inactivation of the Transcriptional Regulator SugR{triangledown}

Bastian Blombach, Annette Arndt,§ Marc Auchter, and Bernhard J. Eikmanns*

Institute of Microbiology and Biotechnology, University of Ulm, D-89069 Ulm, Germany

Received 14 October 2008/ Accepted 6 December 2008

Pyruvate dehydrogenase complex-deficient strains of Corynebacterium glutamicum produce L-valine from glucose only after depletion of the acetate required for growth. Here we show that inactivation of the DeoR-type transcriptional regulator SugR or replacement of acetate by ethanol already in course of the growth phase results in efficient L-valine production.

* Corresponding author. Mailing address: Institute of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany. Phone: 49 (0) 731 50 22707. Fax: 49 (0) 731 50 22719. E-mail: bernhard.eikmanns{at}uni-ulm.de

{triangledown} Published ahead of print on 16 December 2008.

§ Present address: Forsyth Institute, Boston, MA 02115.

Applied and Environmental Microbiology, February 2009, p. 1197-1200, Vol. 75, No. 4
0099-2240/09/$08.00+0     doi:10.1128/AEM.02351-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»