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Applied and Environmental Microbiology, March 2009, p. 1674-1678, Vol. 75, No. 6
0099-2240/09/$08.00+0     doi:10.1128/AEM.02274-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Silver-Palladium Surfaces Inhibit Biofilm Formation{triangledown}

Wen-Chi Chiang,1 Casper Schroll,1 Lisbeth Rischel Hilbert,1 Per Møller,1 and Tim Tolker-Nielsen2*

Department of Mechanical Engineering, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark,1 Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark2

Received 3 October 2008/ Accepted 7 January 2009

Undesired biofilm formation is a major concern in many areas. In the present study, we investigated biofilm-inhibiting properties of a silver-palladium surface that kills bacteria by generating microelectric fields and electrochemical redox processes. For evaluation of the biofilm inhibition efficacy and study of the biofilm inhibition mechanism, the silver-sensitive Escherichia coli J53 and the silver-resistant E. coli J53[pMG101] strains were used as model organisms, and batch and flow chamber setups were used as model systems. In the case of the silver-sensitive strain, the silver-palladium surfaces killed the bacteria and prevented biofilm formation under conditions of low or high bacterial load. In the case of the silver-resistant strain, the silver-palladium surfaces killed surface-associated bacteria and prevented biofilm formation under conditions of low bacterial load, whereas under conditions of high bacterial load, biofilm formation occurred upon a layer of surface-associated dead bacteria.

* Corresponding author. Mailing address: Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark. Phone: 45 35326656. Fax: 45 35327853. E-mail: ttn{at}sund.ku.dk

{triangledown} Published ahead of print on 16 January 2009.

Applied and Environmental Microbiology, March 2009, p. 1674-1678, Vol. 75, No. 6
0099-2240/09/$08.00+0     doi:10.1128/AEM.02274-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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