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Applied and Environmental Microbiology, March 2009, p. 1793-1795, Vol. 75, No. 6
0099-2240/09/$08.00+0     doi:10.1128/AEM.02033-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

The Salmonella Pathogenicity Island 2-Encoded Type III Secretion System Is Essential for the Survival of Salmonella enterica Serovar Typhimurium in Free-Living Amoebae{triangledown}

Benjamin Bleasdale,1 Penelope J. Lott,1 Aparna Jagannathan,2 Mark P. Stevens,2 Richard J. Birtles,1 and Paul Wigley1*

National Centre for Zoonosis Research and Department of Veterinary Pathology, University of Liverpool, Leahurst, Neston CH64 7TE, United Kingdom,1 Division of Microbiology, Institute for Animal Health, Compton RG20 7NN, United Kingdom2

Received 2 September 2008/ Accepted 12 January 2009

Free-living amoebae represent a potential reservoir and predator of Salmonella enterica. Through the use of type III secretion system (T3SS) mutants and analysis of transcription of selected T3SS genes, we demonstrated that the Salmonella pathogenicity island 2 is highly induced during S. enterica serovar Typhimurium infection of Acanthamoeba polyphaga and is essential for survival within amoebae.

* Corresponding author. Mailing address: National Centre for Zoonosis Research, University of Liverpool, Leahurst Campus, Neston CH64 7TE, United Kingdom. Phone: 44 (0)151 7946193. E-mail: paul.wigley{at}liv.ac.uk

{triangledown} Published ahead of print on 23 January 2009.

Applied and Environmental Microbiology, March 2009, p. 1793-1795, Vol. 75, No. 6
0099-2240/09/$08.00+0     doi:10.1128/AEM.02033-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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