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Applied and Environmental Microbiology, April 2009, p. 2577-2580, Vol. 75, No. 8
0099-2240/09/$08.00+0     doi:10.1128/AEM.02921-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Spontaneous Quinolone Resistance in the Zoonotic Serovar of Vibrio vulnificus{triangledown} ,{dagger}

Francisco J. Roig, A. Llorens, B. Fouz, and C. Amaro*

Departamento de Microbiología, Facultad de Biología, Universidad de Valencia, Valencia, Spain

Received 22 December 2008/ Accepted 4 February 2009

This work demonstrates that Vibrio vulnificus biotype 2, serovar E, an eel pathogen able to infect humans, can become resistant to quinolone by specific mutations in gyrA (substitution of isoleucine for serine at position 83) and to some fluoroquinolones by additional mutations in parC (substitution of lysine for serine at position 85). Thus, to avoid the selection of resistant strains that are potentially pathogenic for humans, antibiotics other than quinolones must be used to treat vibriosis on farms.

* Corresponding author. Mailing address: Departamento de Microbiología, Facultad de Biología, Universidad de Valencia, Valencia, Spain. Phone: 00 34 96 354 31 04. Fax: 00 34 96 354 45 70. E-mail: carmen.amaro{at}uv.es

{triangledown} Published ahead of print on 13 February 2009.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

Applied and Environmental Microbiology, April 2009, p. 2577-2580, Vol. 75, No. 8
0099-2240/09/$08.00+0     doi:10.1128/AEM.02921-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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