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Appl Environ Microbiol. 1961 July; 9(4): 325-334

Rifomycin

XIV. Production of Rifomycin B

P. Margalith1 and H. Pagani

Research Laboratories Lepetit S.p.A., Milan, Italy

ABSTRACT

The production of a fraction of the rifomycin complex (rifomycin B) by Streptomyces mediterranei has been described. Both qualitative and quantitative aspects of the fermentation are determined by suitable agitation-aeration parameters. In addition to conventional nutrient ingredients, the presence of some of the barbituric acid derivatives was found to be essential for rifomycin B production. An attempt was made to explain the mode of action of these compounds.

FOOTNOTES

1 Present address: Department of Microbiology, Israel Institute of Technology, Technion, Haifa, Israel.

Appl Environ Microbiol. 1961 July; 9(4): 325-334






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