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Appl Environ Microbiol. 1961 September; 9(5): 372-375

16{alpha}-Hydroxy Steroids

XI. 2ß- and 16{alpha}-Hydroxylation of 9{alpha}-Fluorohydrocortisone by Strains of Streptomyces roseochromogenes

Joseph J. Goodman and Leland L. Smith

Chemical Process Improvement Department, Lederle Laboratories, American Cyanamid Company, Pearl River, New York

ABSTRACT

9{alpha}-Fluorohydrocortisone is hydroxylated by Streptomyces roseochromogenes in the 16{alpha}-, the 2ß-, and in both the 16{alpha}- and 2ß- positions. 16{alpha}-Hydroxylation appears to be the more predominant and rapid pathway of transformation. The degree of 2ß-hydroxylation is dependent upon the strain used and may be increased to the point of its being a major route or virtually eliminated by the proper selection of isolates.

Appl Environ Microbiol. 1961 September; 9(5): 372-375






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