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Appl Environ Microbiol. 1961 November; 9(6): 502-507

Oxytetracycline Formation by Streptomyces rimosus in Chemically Defined Media

Department of Nutritional and Biochemical Research, Mead Johnson Research Center, Mead Johnson and Company, Evansville, Indiana

ABSTRACT

Details in the fermentation of oxytetracycline in a synthetic medium with Streptomyces rimosus have been presented. In these studies, an organic nitrogen source was shown to be essential for the production of significant amounts of antibiotic activity. Of the amino acids tested, aspartic acid, proline, threonine, valine, and ß-alanine were utilized well for both growth and antibiotic production. Markedly different fermentation patterns were observed with aspartic acid and ß-alanine. Glycerol and glucose supported antibiotic yields superior to those found with other carbohydrates tested. Short chain organic acids were not effectively utilized for growth in the absence of a readily fermentable carbohydrate.