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Appl Environ Microbiol. 1961 November; 9(6): 524-528

In Vitro Activity of Actinospectacin in Human Whole Blood

W. T. Sokolski, C. G. Chidester and L. K. Schadewald

Biological Control, The Upjohn Company, Kalamazoo, Michigan

ABSTRACT

A method for testing antibacterial substances in whole blood is described. The test agent for the method was actinospectacin which reportedly has good in vivo activity, approximately in the range with chloramphenicol, but relatively poor in vitro activity in the common media. In human whole blood, however, the in vitro activity compares favorably with chloramphenicol thus indicating that whole blood may predict in vivo activity better than the usual bacteriological media.

Appl Environ Microbiol. 1961 November; 9(6): 524-528






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