AEM Accepts, published online ahead of print on 30 October 2009

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Appl. Environ. Microbiol. doi:10.1128/AEM.01761-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Diverse Genetic Markers Concordantly Identify Bovine-origin Escherichia coli O157 Genotypes Under-represented in Human Disease

Joshua Whitworth, Yubei Zhang, James Bono, Eve Pleydell, Nigel French, and Thomas Besser^*

Department of Veterinary Microbiology and Pathology, Washington State University College of Veterinary Medicine, Pullman, WA 99164, USA; U.S. Meat Animal Research Center, Agricultural Research Service, U.S. Department of Agriculture, Clay Center, Nebraska 68933-0166, USA; Institute of Veterinary, Animal, and Biomedical Sciences, Massey University, Palmerston North, New Zealand

^* To whom correspondence should be addressed. Email: tbesser{at}vetmed.wsu.edu.

Genetic markers previously reported to occur at significantly different frequencies in isolates of Escherichia coli O157:H7 obtained from cattle and from clinically affected humans concordantly delineate at least five genetic groups. Isolates in three of these groups consistently carry one or more markers rarely found among clinical isolates.