AEM Accepts, published online ahead of print on 19 January 2007
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Appl. Environ. Microbiol. doi:10.1128/AEM.02218-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Does antibacterial activity of silver nanoparticle depend on shape of nanoparticle? A study on Gram-negative E. coli

Sukdeb Pal, Yu Kyung Tak, and Joon Myong Song*

Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 151-742, South Korea

* To whom correspondence should be addressed. Email: jmsong{at}snu.ac.kr.


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Abstract

In this work we investigated the antibacterial properties of different shapes of silver nanoparticles on Gram-negative E.coli bacteria, both in liquid systems and on agar plates. Energy-filtering transmission electron microscopy (EFTEM) images illustrate considerable changes in the cell membranes upon treatment, resulting in the cell death. Truncated triangular silver nanoplates with a {111} lattice plane as the basal plane displayed the strongest biocidal action compared with spherical, rod shaped nanoparticles or with Ag+ (in the form of AgNO3). It is proposed that the nanoscaled size and presence of {111} plane combine to promote this biocidal property. To our knowledge this work for the first time presents a comparative study on the bactericidal properties of the silver nanoparticles of different shapes and our results demonstrate that silver nanoparticles undergo a shape dependent interaction with Gram-negative E.coli.




This article has been cited by other articles:

  • Egger, S., Lehmann, R. P., Height, M. J., Loessner, M. J., Schuppler, M. (2009). Antimicrobial Properties of a Novel Silver-Silica Nanocomposite Material. Appl. Environ. Microbiol. 75: 2973-2976 [Abstract] [Full Text]  
  • Jung, W. K., Koo, H. C., Kim, K. W., Shin, S., Kim, S. H., Park, Y. H. (2008). Antibacterial Activity and Mechanism of Action of the Silver Ion in Staphylococcus aureus and Escherichia coli. Appl. Environ. Microbiol. 74: 2171-2178 [Abstract] [Full Text]  


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