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Appl. Environ. Microbiol., Nov 1996, 4284-4287, Vol 62, No. 11
Copyright © 1996, American Society for Microbiology

Inhibitory Effects of Secondary Metabolites from the Red Alga Delisea pulchra on Swarming Motility of Proteus mirabilis

L Gram, R de Nys, R Maximilien, M Givskov, P Steinberg and S Kjelleberg
School of Microbiology and Immunology and School of Biological Science, University of New South Wales, 2036 Kensington, Australia, and Department of Seafood Research, Danish Institute for Fisheries Research, and Department of Microbiology, Technical University of Denmark, DK-2800 Lyngby, Denmark

Abnormal, uncoordinated swarming motility of the opportunistic human pathogen Proteus mirabilis was seen when a crude extract of the Australian red alga Delisea pulchra was added to the medium. This occurred at concentrations at which growth rate, swimming motility, cell elongation, polynucleation, and hyperflagellation were not affected. One halogenated furanone from D. pulchra inhibited swarming motility at concentrations that did not affect growth rate and swimming motility. Other structurally similar D. pulchra furanones had no effect on swarming, suggesting considerable specificity in the effects of furanones on swarming motility by P. mirabilis.


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