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Applied and Environmental Microbiology, August 1998, p. 3106-3109, Vol. 64, No. 8
0099-2240/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Fungal Biotransformation of 6-Nitrochrysene

Jairaj V. Pothuluri,* John B. Sutherland, James P. Freeman, and Carl E. Cerniglia

National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079

Received 27 February 1998/Accepted 1 June 1998

The fungus Cunninghamella elegans was used to biotransform 6-nitrochrysene, a mutagen that is a widespread environmental contaminant. After 6 days, 74% of the 3H-labeled 6-nitrochrysene added had been metabolized to two isomeric sulfate conjugates. These conjugates were separated by high-performance liquid chromatography and identified by UV-visible, 1H nuclear magnetic resonance, and mass spectral techniques as 6-nitrochrysene 1-sulfate and 6-nitrochrysene 2-sulfate.

* Corresponding author. Mailing address: Division of Microbiology, HFT-250, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079. Phone: (870) 543-7597. Fax: (870) 543-7307. E-mail: Jpothuluri{at}nctr.fda.gov.

Applied and Environmental Microbiology, August 1998, p. 3106-3109, Vol. 64, No. 8
0099-2240/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.




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