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Applied and Environmental Microbiology, September 1998, p. 3496-3498, Vol. 64, No. 9
0099-2240/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Genetically Modified Ruminal Bacteria Protect Sheep from Fluoroacetate Poisoning

Keith Gregg,* Brenton Hamdorf,dagger Kerrin Henderson, Jan Kopecny,Dagger and Cheryl Wong

Rumen Biotech, Murdoch University, Murdoch, Western Australia 6150, Australia

Received 30 March 1998/Accepted 9 June 1998

Four strains of Butyrivibrio fibrisolvens, transformed with a gene encoding fluoroacetate dehalogenase, maintained a combined population of 106 to 107 cells ml-1 in the rumens of test sheep. Five inoculated sheep showed markedly reduced toxicological symptoms after fluoroacetate poisoning when behavioral, physiological, and histological effects were compared with those of five uninoculated control sheep.

* Corresponding author. Mailing address: Rumen Biotech, Murdoch University, South Street, Murdoch, WA 6150, Australia. Phone: (61) 8 9360 2122. Fax: (61) 8 9360 6303. E-mail: K.Gregg{at}murdoch.edu.au.

dagger Present address: Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia.

Dagger Present address: Institute of Animal Physiology and Genetics, Prague, Czech Republic.

Applied and Environmental Microbiology, September 1998, p. 3496-3498, Vol. 64, No. 9
0099-2240/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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