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Applied and Environmental Microbiology, December 1999, p. 5631-5635, Vol. 65, No. 12
0099-2240/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Characterization of a Bacteriocin-Like Substance Produced by a Vaginal Lactobacillus salivarius Strain

Virginia S. Ocaña,1 Aída A. Pesce de Ruiz Holgado,1,2 and María Elena Nader-Macías1,2,*

CERELA1 and Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán,2 Tucumán, Argentina

Received 30 April 1999/Accepted 1 October 1999

A novel bacteriocin-like substance produced by vaginal Lactobacillus salivarius subsp. salivarius CRL 1328 with activity against Enterococcus faecalis, Enterococcus faecium, and Neisseria gonorrhoeae was characterized. The highest level of production of this heat-resistant peptide or protein occurred during the late exponential phase. Its mode of action was shown to be bactericidal. L. salivarius subsp. salivarius CRL 1328 could be used for the design of a probiotic to prevent urogenital infections.

* Corresponding author. Mailing address: CERELA, Chacabuco 145, 4000 Tucumán, Argentina. Phone: (381) 431-1720. Fax: (381) 431-0465. E-mail: mmacias{at}cerela.org.ar.

Applied and Environmental Microbiology, December 1999, p. 5631-5635, Vol. 65, No. 12
0099-2240/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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