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Applied and Environmental Microbiology, June 1999, p. 2754-2757, Vol. 65, No. 6
0099-2240/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

BACTOX, a Rapid Bioassay That Uses Protozoa To Assess the Toxicity of Bacteria

Wolfram Schlimme,1 Marcello Marchiani,1 Kurt Hanselmann,2 and Bernard Jenni1,*

Novartis Pharma AG, CH-4002 Basel,1 and Department of Microbiology, Institute of Plant Biology, University of Zürich, 8008 Zürich,2 Switzerland

Received 25 September 1998/Accepted 18 March 1999

A new type of toxicity test based on the protozoan Tetrahymena pyriformis has been developed to assess the overall toxicity of bacterial strains given as prey. This simple and rapid test is able to detect toxicant-producing bacteria, which may present a biohazard. It can also be used for the risk assessment of microbes designed for deliberate release.

* Corresponding author. Mailing address: Novartis Pharma AG, K-135.P.16, CH-4002 Basel, Switzerland. Phone: 41-61-696.58.01. Fax: 41-61-696.16.49. E-mail: bernard.jenni{at}pharma.novartis.com.

Applied and Environmental Microbiology, June 1999, p. 2754-2757, Vol. 65, No. 6
0099-2240/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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