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Applied and Environmental Microbiology, December 2000, p. 5241-5247, Vol. 66, No. 12
0099-2240/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Characterization of Bacillus Species Used for Oral Bacteriotherapy and Bacterioprophylaxis of Gastrointestinal Disorders

Ngo Thi Hoa,1 Loredana Baccigalupi,2 Ashley Huxham,1 Andrei Smertenko,1 Pham Hung Van,3 Sergio Ammendola,4 Ezio Ricca,2 and And Simon M. Cutting1,*

School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 0EX, United Kingdom1; Section of Microbiology, Department of General and Environmental Physiology, University Federico II, 80134 Naples,2 and Bioprogress S.p.A., Anagni (FR),4 Italy; and Laboratory of Microbiology, Ho Chi Minh University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam3

Received 16 June 2000/Accepted 6 September 2000

Bacillus subtilis spores are being used for oral bacteriotherapy and bacterioprophylaxis of gastrointestinal disorders in both humans and animals. Since B. subtilis is an aerobic saprophyte, how spores may benefit the gut microbiota is an intriguing question, since other probiotics such as Lactobacillus spp. which colonize the gut are anerobes. As a first step in understanding the potential effects of ingesting spores, we have characterized five commercial products. An extensive biochemical, physiological, and phylogenetic analysis has revealed that four of these products are mislabeled. Moreover, four of these products showed high levels of antibiotic resistance.

* Corresponding author. Mailing address: School of Biological Sciences, Royal Holloway University of London, Egham, Surrey, TW20 0EX, UK. Tel: 01784-443760; Fax: 01784-434326; E-mail: s.cutting{at}rhbnc.ac.uk.

Applied and Environmental Microbiology, December 2000, p. 5241-5247, Vol. 66, No. 12
0099-2240/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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