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Applied and Environmental Microbiology, March 2000, p. 1202-1204, Vol. 66, No. 3
0099-2240/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Reductive Cleavage of Demeton-S-Methyl by Corynebacterium glutamicum in Cometabolism on More Readily Metabolizable Substrates

Laurence Girbal,1,* Didier Hilaire,2 Sébastien Leduc,1 Laure Delery,1 Jean-Luc Rols,1 and Nicholas D. Lindley1

Laboratoire de Biotechnologie-Bioprocédés, UMR CNRS 5504 and UMR INRA 792, Centre de Bioingénierie Gilbert Durand, INSA, 31077 Toulouse cedex 4,1 and Centre d'Etudes du Bouchet, DGA, 91710 Vert-Le-Petit,2 France

Received 7 July 1999/Accepted 22 November 1999

Corynebacterium glutamicum is able to biotransform demeton-S-methyl, an organophosphorus compound, during cometabolism with more readily metabolizable substrates. Among the cosubstrates used, fructose is the growth substrate that is most favorable for demeton-S-methyl biotransformation. The reaction mechanism of demeton-S-methyl biotransformation involves reductive cleavage of an S-C bond, which leads to accumulation of dimethyl thiophosphate in the culture medium.

* Corresponding author. Mailing address: Laboratoire de Biotechnologie-Bioprocédés, Centre de Bioingénierie Gilbert Durand, INSA, 135 Avenue de Rangueil, 31077 Toulouse cedex 4, France. Phone: 33 5 61 55 94 19. Fax: 33 5 61 55 94 02. E-mail: girbal{at}insa-tlse.fr.

Applied and Environmental Microbiology, March 2000, p. 1202-1204, Vol. 66, No. 3
0099-2240/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Netzer, R., Peters-Wendisch, P., Eggeling, L., Sahm, H. (2004). Cometabolism of a Nongrowth Substrate: L-Serine Utilization by Corynebacterium glutamicum. Appl. Environ. Microbiol. 70: 7148-7155 [Abstract] [Full Text]  


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