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Applied and Environmental Microbiology, August 2000, p. 3646-3649, Vol. 66, No. 8
0099-2240/00/$04.00+0

Transformation of Amoxapine by Cunninghamella elegans

Joanna D. Moody,1 Donglu Zhang,2 Thomas M. Heinze,3 and Carl E. Cerniglia1,*

Division of Microbiology1 and Division of Chemistry,3 National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, and Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Princeton, New Jersey 085022

Received 18 January 2000/Accepted 16 May 2000

We examined Cunninghamella elegans to determine its ability to transform amoxapine, a tricyclic antidepressant belonging to the dibenzoxazepine class of drugs. Approximately 57% of the exogenous amoxapine was metabolized to three metabolites that were isolated by high-performance liquid chromatography and were identified by nuclear magnetic resonance and mass spectrometry as 7-hydroxyamoxapine (48%), N-formyl-7-hydroxyamoxapine (31%), and N-formylamoxapine (21%). 7-Hydroxyamoxapine, a mammalian metabolite with biological activity, now can be produced in milligram quantities for toxicological evaluation.

* Corresponding author. Mailing address: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079-9502. Phone: (870) 543-7341. Fax: (870) 543-7307. E-mail: CCerniglia{at}nctr.fda.gov.

Applied and Environmental Microbiology, August 2000, p. 3646-3649, Vol. 66, No. 8
0099-2240/00/$04.00+0


This article has been cited by other articles:

  • Sun, L., Huang, H.-H., Liu, L., Zhong, D.-F. (2004). Transformation of Verapamil by Cunninghamella blakesleeana. Appl. Environ. Microbiol. 70: 2722-2727 [Abstract] [Full Text]  
  • Moody, J. D., Freeman, J. P., Fu, P. P., Cerniglia, C. E. (2002). Biotransformation of Mirtazapine by Cunninghamella Elegans. Drug Metab. Dispos. 30: 1274-1279 [Abstract] [Full Text]  
  • Cha, C.-J., Doerge, D. R., Cerniglia, C. E. (2001). Biotransformation of Malachite Green by the Fungus Cunninghamella elegans. Appl. Environ. Microbiol. 67: 4358-4360 [Abstract] [Full Text]  


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