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Applied and Environmental Microbiology, April 2001, p. 1689-1692, Vol. 67, No. 4
0099-2240/01/$04.00+0   DOI: 10.1128/AEM.67.4.1689-1692.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Enterocin P Selectively Dissipates the Membrane Potential of Enterococcus faecium T136

C. Herranz,1 Y. Chen,2 H.-J. Chung,2 L. M. Cintas,1 P. E. Hernández,1 T. J. Montville,2 and M. L. Chikindas2,*

Departmento de Nutrición y Bromatología III, Facultad de Veterinaria, Universidad Complutense, 28040 Madrid, Spain,1 and Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 089012

Received 25 September 2000/Accepted 5 February 2001

Enterocin P is a pediocin-like, broad-spectrum bacteriocin which displays a strong inhibitory activity against Listeria monocytogenes. The bacteriocin was purified from the culture supernatant of Enterococcus faecium P13, and its molecular mechanism of action against the sensitive strain E. faecium T136 was evaluated. Although enterocin P caused significant reduction of the membrane potential (Delta Psi ) and the intracellular ATP pool of the indicator organism, the pH gradient (Delta pH) component of the proton motive force (Delta p) was not dissipated. By contrast, enterocin P caused carboxyfluorescein efflux from E. faecium T136-derived liposomes.

* Corresponding author. Mailing address: Department of Food Science, Rutgers, The State University of New Jersey, 65 Dudley Rd., New Brunswick, NJ 08901-8520. Phone: (732) 932-9661, ext. 218. Fax: (732) 932-6776. E-mail: tchikindas{at}aesop.rutgers.edu.

Applied and Environmental Microbiology, April 2001, p. 1689-1692, Vol. 67, No. 4
0099-2240/01/$04.00+0   DOI: 10.1128/AEM.67.4.1689-1692.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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