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Applied and Environmental Microbiology, August 2001, p. 3739-3745, Vol. 67, No. 8
0099-2240/01/$04.00+0   DOI: 10.1128/AEM.67.8.3739-3745.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Isolation and In Vivo and In Vitro Antifungal Activity of Phenylacetic Acid and Sodium Phenylacetate from Streptomyces humidus

Byung Kook Hwang,1,* Song Won Lim,1 Beom Seok Kim,1 Jung Yeop Lee,1 and Surk Sik Moon2

Laboratory of Molecular Plant Pathology, College of Life and Environmental Sciences, Korea University, Seoul 136-701,1 and Department of Chemistry, Kongju National University, Kongju 314-701,2 Korea

Received 7 February 2001/Accepted 30 May 2001

The antifungal substances SH-1 and SH-2 were isolated from Streptomyces humidus strain S5-55 cultures by various purification procedures and identified as phenylacetic acid and sodium phenylacetate, respectively, based on the nuclear magnetic resonance, electron ionization mass spectral, and inductively coupled plasma mass spectral data. SH-1 and SH-2 completely inhibited the growth of Pythium ultimum, Phytophthora capsici, Rhizoctonia solani, Saccharomyces cerevisiae, and Pseudomonas syringae pv. syringae at concentrations from 10 to 50 µg/ml. The two compounds were as effective as the commercial fungicide metalaxyl in inhibiting spore germination and hyphal growth of P. capsici. However, the in vivo control efficacies of the two antifungal compounds against P. capsici infection on pepper plants were similar to those of H3PO3 and fosetyl-AI but less than that of metalaxyl.

* Corresponding author. Mailing address: Laboratory of Molecular Plant Pathology, College of Life and Environmental Sciences, Korea University, Seoul 136-701, Korea. Phone: (82) 2 3290 3061. Fax: (82) 2 925 1970. E-mail: bkhwang{at}korea.ac.kr.

Applied and Environmental Microbiology, August 2001, p. 3739-3745, Vol. 67, No. 8
0099-2240/01/$04.00+0   DOI: 10.1128/AEM.67.8.3739-3745.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Somers, E., Ptacek, D., Gysegom, P., Srinivasan, M., Vanderleyden, J. (2005). Azospirillum brasilense Produces the Auxin-Like Phenylacetic Acid by Using the Key Enzyme for Indole-3-Acetic Acid Biosynthesis. Appl. Environ. Microbiol. 71: 1803-1810 [Abstract] [Full Text]  
  • Lee, J. Y., Moon, S. S., Hwang, B. K. (2003). Isolation and Antifungal and Antioomycete Activities of Aerugine Produced by Pseudomonas fluorescens Strain MM-B16. Appl. Environ. Microbiol. 69: 2023-2031 [Abstract] [Full Text]  


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