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Applied and Environmental Microbiology, August 2001, p. 3763-3766, Vol. 67, No. 8
0099-2240/01/$04.00+0   DOI: 10.1128/AEM.67.8.3763-3766.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Antibiotic Resistance in Salmonella enterica Serovar Typhimurium Exposed to Microcin-Producing Escherichia coli

Steve A. Carlson,1,* Timothy S. Frana,2 and Ronald W. Griffith2

Preharvest Food Safety and Enteric Disease Research Unit, National Animal Disease Center, U.S. Department of Agriculture Agricultural Research Service, Ames, Iowa 50010,1 and Department of Veterinary Microbiology and Preventive Medicine, Iowa State University College of Veterinary Medicine, Ames, Iowa 500112

Received 26 March 2001/Accepted 23 May 2001

Microcin 24 is an antimicrobial peptide secreted by uropathogenic Escherichia coli. Secretion of microcin 24 provides an antibacterial defense mechanism for E. coli. In a plasmid-based system using transformed Salmonella enterica, we found that resistance to microcin 24 could be seen in concert with a multiple-antibiotic resistance phenotype. This multidrug-resistant phenotype appeared when Salmonella was exposed to an E. coli strain expressing microcin 24. Therefore, it appears that multidrug-resistant Salmonella can arise as a result of an insult from other pathogenic bacteria.

* Corresponding author. Mailing address: USDA-ARS, National Animal Disease Center, 2300 Dayton Rd., Box 70, Ames, IA 50010. Phone: (515) 663-7612. Fax: (515) 663-7373. E-mail: scarlson{at}nadc.ars.usda.gov.

Applied and Environmental Microbiology, August 2001, p. 3763-3766, Vol. 67, No. 8
0099-2240/01/$04.00+0   DOI: 10.1128/AEM.67.8.3763-3766.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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