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Applied and Environmental Microbiology, February 2003, p. 1305-1307, Vol. 69, No. 2
0099-2240/03/$08.00+0     DOI: 10.1128/AEM.69.2.1305-1307.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Studies on the Mode of Action of Reutericyclin

Michael G. Gänzle* and Rudi F. Vogel

Lehrstuhl für Technische Mikrobiologie, TU München, 85350 Freising, Germany

Received 8 April 2002/ Accepted 1 November 2002

The mode of action of reutericyclin was determined with fluorescent dyes that probed the permeability of the cytoplasmic membrane by large molecules, protons, and potassium. A comparison of reutericyclin activity with those of nisin, nigericin, and valinomycin demonstrated that reutericyclin does not form pores but selectively dissipates the transmembrane proton potential.

* Corresponding author. Mailing address: TU München, Lehrstuhl für Technische Mikrobiologie, Weihenstephaner Steig 16, 85350 Freising, Germany. Phone: 49 8161 71 3959. Fax: 49 8161 71 3327. E-mail: michael.gaenzle{at}wzw.tum.de.

Applied and Environmental Microbiology, February 2003, p. 1305-1307, Vol. 69, No. 2
0099-2240/03/$08.00+0     DOI: 10.1128/AEM.69.2.1305-1307.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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