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Applied and Environmental Microbiology, March 2003, p. 1840-1843, Vol. 69, No. 3
0099-2240/03/$08.00+0     DOI: 10.1128/AEM.69.3.1840-1843.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Antigenic Hepatitis A Virus Structures May Be Produced in Escherichia coli

Glòria Sánchez, Santiago Caballero, Susana Guix, Albert Bosch,* and Rosa M. Pintó

Enteric Virus Laboratory, Department of Microbiology, University of Barcelona, 08028 Barcelona, Spain

Received 7 October 2002/ Accepted 17 December 2002

The synthesis of 14S pentamers and 70S empty capsids of hepatitis A virus (HAV) has been accomplished by expressing the viral genome for periods of time longer than 4 h in Escherichia coli. HAV pentamers (14S) self-assembled into capsids (70S) in vitro. The antibodies induced by these structures recognized and neutralized HAV.

* Corresponding author. Mailing address: Dept. of Microbiology, University of Barcelona, Av. Diagonal 645, 08028 Barcelona, Spain. Phone: 34 934034620. Fax: 34 934034629. E-mail: abosch{at}ub.edu.

Applied and Environmental Microbiology, March 2003, p. 1840-1843, Vol. 69, No. 3
0099-2240/03/$08.00+0     DOI: 10.1128/AEM.69.3.1840-1843.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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