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Applied and Environmental Microbiology, June 2003, p. 3646-3649, Vol. 69, No. 6
0099-2240/03/$08.00+0     DOI: 10.1128/AEM.69.6.3646-3649.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Characterization of the First Molluscicidal Lipopolysaccharide from Moraxella osloensis

Li Tan{dagger} and Parwinder S. Grewal*

Department of Entomology, Ohio Agricultural Research and Development Center, Ohio State University, Wooster, Ohio 44691

Received 20 November 2002/ Accepted 24 February 2003

Moraxella osloensis is a bacterium that is mutualistically associated with Phasmarhabditis hermaphrodita, a nematode that has potential for the biocontrol of mollusk pests, especially the slug Deroceras reticulatum. We discovered that purified M. osloensis lipopolysaccharide (LPS) possesses a lethal toxicity to D. reticulatum when administered by injection but no contact or oral toxicity to this slug. The toxicity of the LPS resides in the lipid A moiety. M. osloensis LPS was semiquantitated at 6 x 107 endotoxin units per mg. The LPS is a rough-type LPS with an estimated molecular weight of 5,300. Coinjection of galactosamine with the LPS increased the LPS's toxicity to the slug two- to four-fold. The galactosamine-induced sensitization of the slug to the LPS was reversed completely by uridine.

* Corresponding author. Mailing address: Department of Entomology, Ohio State University, OARDC, Wooster, OH 44691. Phone: (330) 263-3963. Fax: (330) 263-3686. E-mail: grewal.4{at}osu.edu.

{dagger} Present address: Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294-2170.

Applied and Environmental Microbiology, June 2003, p. 3646-3649, Vol. 69, No. 6
0099-2240/03/$08.00+0     DOI: 10.1128/AEM.69.6.3646-3649.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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