This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Richter, D.
Right arrow Articles by Matuschka, F.-R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Richter, D.
Right arrow Articles by Matuschka, F.-R.
Agricola
Right arrow Articles by Richter, D.
Right arrow Articles by Matuschka, F.-R.

 Previous Article  |  Next Article 

Applied and Environmental Microbiology, November 2004, p. 6414-6419, Vol. 70, No. 11
0099-2240/04/$08.00+0     DOI: 10.1128/AEM.70.11.6414-6419.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Relationships of a Novel Lyme Disease Spirochete, Borrelia spielmani sp. nov., with Its Hosts in Central Europe

Dania Richter,* Daniela B. Schlee, Rainer Allgöwer, and Franz-Rainer Matuschka

Abteilung Parasitologie, Institut für Pathologie, Charité, Humboldt-Universität zu Berlin, Berlin, Germany

Received 25 March 2004/ Accepted 29 June 2004

To determine whether the pathogenic variant of Lyme disease spirochetes, isolate A14S, is perpetuated in a particular reservoir-vector relationship, we screened vector ticks in various Central European sites for a related spirochete and determined its host association. A14S-like spirochetes infect numerous questing ticks in the Petite Camargue Alsacienne (PC). They frequently infect dormice, but no mice or voles. Garden dormice appear to be better reservoir hosts for A14S-like spirochetes than for Borrelia afzelii, because these spirochetes are retained longer and infect ticks more readily. Spirochetes associated with garden dormice in the PC site form a homologous entity with those isolated from a human patient in The Netherlands. Its unique biological relationship together with previous genetic characterization justifies designating this dormouse-associated genospecies as a distinct entity. Garden dormice serve as the main reservoir hosts of a novel genospecies, Borrelia spielmani sp. nov., one of several that cause Lyme disease in people.

* Corresponding author. Mailing address: Abteilung Parasitologie, Institut für Pathologie, Charité, Humboldt-Universität zu Berlin, Malteserstraße 74-100, 12249 Berlin, Germany. Phone: 49 30 838 70 372. Fax: 49 30 776 2085. E-mail: drichter{at}charite.de.

Applied and Environmental Microbiology, November 2004, p. 6414-6419, Vol. 70, No. 11
0099-2240/04/$08.00+0     DOI: 10.1128/AEM.70.11.6414-6419.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Krupka, I., Knauer, J., Lorentzen, L., O'Connor, T. P., Saucier, J., Straubinger, R. K. (2009). Borrelia burgdorferi Sensu Lato Species in Europe Induce Diverse Immune Responses against C6 Peptides in Infected Mice. CVI 16: 1546-1562 [Abstract] [Full Text]  
  • Morgenstern, K., Baljer, G., Norris, D. E., Kraiczy, P., Hanssen-Hubner, C., Hunfeld, K.-P. (2009). In Vitro Susceptibility of Borrelia spielmanii to Antimicrobial Agents Commonly Used for Treatment of Lyme Disease. Antimicrob. Agents Chemother. 53: 1281-1284 [Abstract] [Full Text]  
  • Imachi, H., Sakai, S., Hirayama, H., Nakagawa, S., Nunoura, T., Takai, K., Horikoshi, K. (2008). Exilispira thermophila gen. nov., sp. nov., an anaerobic, thermophilic spirochaete isolated from a deep-sea hydrothermal vent chimney. Int. J. Syst. Evol. Microbiol. 58: 2258-2265 [Abstract] [Full Text]  
  • (2008). MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi. Proc. Natl. Acad. Sci. USA 105: 8730-8735  
  • Kraiczy, P., Seling, A., Brissette, C. A., Rossmann, E., Hunfeld, K.-P., Bykowski, T., Burns, L. H., Troese, M. J., Cooley, A. E., Miller, J. C., Brade, V., Wallich, R., Casjens, S., Stevenson, B. (2008). Borrelia burgdorferi Complement Regulator-Acquiring Surface Protein 2 (CspZ) as a Serological Marker of Human Lyme Disease. CVI 15: 484-491 [Abstract] [Full Text]  
  • Saito, K., Ito, T., Asashima, N., Ohno, M., Nagai, R., Fujita, H., Koizumi, N., Takano, A., Watanabe, H., Kawabata, H. (2007). Borrelia valaisiana Infection in a Japanese Man Associated with Traveling to Foreign Countries. Am J Trop Med Hyg 77: 1124-1127 [Abstract] [Full Text]  
  • Herzberger, P., Siegel, C., Skerka, C., Fingerle, V., Schulte-Spechtel, U., van Dam, A., Wilske, B., Brade, V., Zipfel, P. F., Wallich, R., Kraiczy, P. (2007). Human Pathogenic Borrelia spielmanii sp. nov. Resists Complement-Mediated Killing by Direct Binding of Immune Regulators Factor H and Factor H-Like Protein 1. Infect. Immun. 75: 4817-4825 [Abstract] [Full Text]  
  • Richter, D., Matuschka, F.-R. (2006). Perpetuation of the Lyme Disease Spirochete Borrelia lusitaniae by Lizards.. Appl. Environ. Microbiol. 72: 4627-4632 [Abstract] [Full Text]  
  • Richter, D., Postic, D., Sertour, N., Livey, I., Matuschka, F.-R., Baranton, G. (2006). Delineation of Borrelia burgdorferi sensu lato species by multilocus sequence analysis and confirmation of the delineation of Borrelia spielmanii sp. nov.. Int. J. Syst. Evol. Microbiol. 56: 873-881 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»