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Applied and Environmental Microbiology, April 2005, p. 2183-2185, Vol. 71, No. 4
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.4.2183-2185.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Degradation of ß-Hexachlorocyclohexane by Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26

Yuji Nagata,1* Zbynek Prokop,2 Yukari Sato,1 Petr Jerabek,2 Ashwani Kumar,3 Yoshiyuki Ohtsubo,1 Masataka Tsuda,1 and Jirí Damborsky2

Department of Environmental Life Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan,1 National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic,2 Industrial Toxicology Research Center, Lucknow, India3

Received 23 August 2004/ Accepted 22 October 2004

ß-Hexachlorocyclohexane (ß-HCH) is the most recalcitrant among the {alpha}-, ß-, {gamma}-, and {delta}-isomers of HCH and causes serious environmental pollution problems. We demonstrate here that the haloalkane dehalogenase LinB, reported earlier to mediate the second step in the degradation of {gamma}-HCH in Sphingomonas paucimobilis UT26, metabolizes ß-HCH to produce 2,3,4,5,6-pentachlorocyclohexanol.

* Corresponding author. Mailing address: Department of Environmental Life Sciences, Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Sendai 980-8577, Japan. Phone: 81-22-217-5682. Fax: 81-22-217-5699. E-mail: aynaga{at}ige.tohoku.ac.jp.

Applied and Environmental Microbiology, April 2005, p. 2183-2185, Vol. 71, No. 4
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.4.2183-2185.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Jesenska, A., Monincova, M., Koudelakova, T., Hasan, K., Chaloupkova, R., Prokop, Z., Geerlof, A., Damborsky, J. (2009). Biochemical Characterization of Haloalkane Dehalogenases DrbA and DmbC, Representatives of a Novel Subfamily. Appl. Environ. Microbiol. 75: 5157-5160 [Abstract] [Full Text]  
  • Miyazaki, R., Sato, Y., Ito, M., Ohtsubo, Y., Nagata, Y., Tsuda, M. (2006). Complete Nucleotide Sequence of an Exogenously Isolated Plasmid, pLB1, Involved in {gamma}-Hexachlorocyclohexane Degradation. Appl. Environ. Microbiol. 72: 6923-6933 [Abstract] [Full Text]  
  • Sharma, P., Raina, V., Kumari, R., Malhotra, S., Dogra, C., Kumari, H., Kohler, H.-P. E., Buser, H.-R., Holliger, C., Lal, R. (2006). Haloalkane Dehalogenase LinB Is Responsible for {beta}- and {delta}-Hexachlorocyclohexane Transformation in Sphingobium indicum B90A. Appl. Environ. Microbiol. 72: 5720-5727 [Abstract] [Full Text]  


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