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Applied and Environmental Microbiology, January 2006, p. 923-926, Vol. 72, No. 1
0099-2240/06/$08.00+0     doi:10.1128/AEM.72.1.923-926.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

The Bifidobacterium longum NCIMB 702259T ctr Gene Codes for a Novel Cholate Transporter

Claire E. Price,1 Sharon J. Reid,1 Arnold J. M. Driessen,2 and Valerie R. Abratt1*

Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, Cape Town, South Africa,1 University of Groningen, Groningen, The Netherlands2

Received 13 July 2005/ Accepted 2 November 2005

Preexposure of Bifidobacterium longum NCIMB 702259T to cholate caused increased resistance to cholate, chloramphenicol, and erythromycin. The B. longum ctr gene, encoding a cholate efflux transporter, was transformed into the efflux-negative mutant Escherichia coli KAM3, conferring resistance to bile salts and other antimicrobial compounds and causing the efflux of [14C]cholate.

* Corresponding author. Mailing address: Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, 7701 Cape Town, South Africa. Phone: 27 21 6502183. Fax: 27 21 6897573. E-mail: val{at}science.uct.ac.za

Applied and Environmental Microbiology, January 2006, p. 923-926, Vol. 72, No. 1
0099-2240/06/$08.00+0     doi:10.1128/AEM.72.1.923-926.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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