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Applied and Environmental Microbiology, January 2006, p. 972-975, Vol. 72, No. 1
0099-2240/06/$08.00+0     doi:10.1128/AEM.72.1.972-975.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Bilirubin Oxidase Activity of Bacillus subtilis CotA

Shin-ichi Sakasegawa,1* Hidehiko Ishikawa,1 Shigeyuki Imamura,1 Haruhiko Sakuraba,2 Shuichiro Goda,2 and Toshihisa Ohshima2

Asahi Kasei Pharma Corporation, Shizuoka 410-2321, Japan,1 Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2-1 Minamijosanjimacho, Tokushima 770-8506, Japan2

Received 23 August 2005/ Accepted 15 October 2005

The spore coat protein CotA from Bacillus subtilis was previously identified as a laccase. We have now found that CotA also shows strong bilirubin oxidase activity and markedly higher affinity for bilirubin than conventional bilirubin oxidase. This is the first characterization of bilirubin oxidase activity in a bacterial protein.

* Corresponding author. Mailing address: Asahi Kasei Pharma Corporation, Shizuoka 410-2321, Japan. Phone: 81 (0) 558 76 8564. Fax: 81 (0) 558 76 7149. E-mail: sakasegawa.sb{at}om.asahi-kasei.co.jp

Applied and Environmental Microbiology, January 2006, p. 972-975, Vol. 72, No. 1
0099-2240/06/$08.00+0     doi:10.1128/AEM.72.1.972-975.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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