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Applied and Environmental Microbiology, November 2006, p. 7398-7400, Vol. 72, No. 11
0099-2240/06/$08.00+0     doi:10.1128/AEM.01348-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Lactobacillus rhamnosus Strain GG Modulates Intestinal Absorption, Fecal Excretion, and Toxicity of Aflatoxin B1 in Rats{triangledown}

S. Gratz,1,2* M. Täubel,2 R. O. Juvonen,3 M. Viluksela,4 P. C. Turner,5 H. Mykkänen,1 and H. El-Nezami2

Department of Clinical Nutrition, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland,1 Food and Health Research Centre, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland,2 Department of Pharmacology and Toxicology, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland,3 National Public Health Institute, Laboratory of Toxicology, P.O. Box 95, 70701 Kuopio, Finland,4 Centre for Epidemiology and Biostatistics, Molecular Epidemiology Unit, LIGHT Laboratories, University of Leeds, LS2 9JT Leeds, United Kingdom5

Received 12 June 2006/ Accepted 4 September 2006

In this study, the modulation of aflatoxin B1 (AFB1) uptake in rats by administration of the probiotic Lactobacillus rhamnosus GG was demonstrated. Fecal AFB1 excretion in GG-treated rats was increased via bacterial AFB1 binding. Furthermore, AFB1-associated growth faltering and liver injury were alleviated with GG treatment.

* Corresponding author. Mailing address: Department of Clinical Nutrition, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland. Phone: 358-17 163615. Fax: 358-17 162792. E-mail: silvia.gratz{at}uku.fi.

{triangledown} Published ahead of print on 15 September 2006.

Applied and Environmental Microbiology, November 2006, p. 7398-7400, Vol. 72, No. 11
0099-2240/06/$08.00+0     doi:10.1128/AEM.01348-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gratz, S., Wu, Q. K., El-Nezami, H., Juvonen, R. O., Mykkanen, H., Turner, P. C. (2007). Lactobacillus rhamnosus Strain GG Reduces Aflatoxin B1 Transport, Metabolism, and Toxicity in Caco-2 Cells. Appl. Environ. Microbiol. 73: 3958-3964 [Abstract] [Full Text]  


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