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Applied and Environmental Microbiology, September 2006, p. 6405-6410, Vol. 72, No. 9
0099-2240/06/$08.00+0     doi:10.1128/AEM.03011-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Isolation and Characterization of a New T-Even Bacteriophage, CEV1, and Determination of Its Potential To Reduce Escherichia coli O157:H7 Levels in Sheep

Raul R. Raya,1,2 Peter Varey,1 Rebecca A. Oot,1 Michael R. Dyen,1 Todd R. Callaway,3 Tom S. Edrington,3 Elizabeth M. Kutter,1 and Andrew D. Brabban1*

The Evergreen State College, Olympia, Washington 98505,1 Cerela-Conicet, Tucumán, Argentina,2 USDA Agricultural Station, College Station, Texas 778453

Received 21 December 2005/ Accepted 25 June 2006

Bacteriophage CEV1 was isolated from sheep resistant to Escherichia coli O157:H7 colonization. In vitro, CEV1 efficiently infected E. coli O157:H7 grown both aerobically and anaerobically. In vivo, sheep receiving a single oral dose of CEV1 showed a 2-log-unit reduction in intestinal E. coli O157:H7 levels within 2 days compared to levels in the controls.

* Corresponding author. Mailing address: Lab II, The Evergreen State College, Olympia, WA 98505. Phone: (360) 867-4746. Fax: (360) 867-5430. E-mail: brabbana{at}evergreen.edu.

Applied and Environmental Microbiology, September 2006, p. 6405-6410, Vol. 72, No. 9
0099-2240/06/$08.00+0     doi:10.1128/AEM.03011-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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