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Applied and Environmental Microbiology, September 2006, p. 6419-6423, Vol. 72, No. 9
0099-2240/06/$08.00+0     doi:10.1128/AEM.00753-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Quorum Sensing-Disrupting Brominated Furanones Protect the Gnotobiotic Brine Shrimp Artemia franciscana from Pathogenic Vibrio harveyi, Vibrio campbellii, and Vibrio parahaemolyticus Isolates{dagger}

Tom Defoirdt,1,2 Roselien Crab,1,2 Thomas K. Wood,3,{ddagger} Patrick Sorgeloos,2 Willy Verstraete,1* and Peter Bossier2

Laboratory of Microbial Ecology and Technology (LabMET), Ghent University, Coupure Links 653, 9000 Ghent, Belgium,1 Laboratory of Aquaculture and Artemia Reference Center, Ghent University, Rozier 44, 9000 Ghent, Belgium,2 Departments of Chemical Engineering and Molecular and Cell Biology, University of Connecticut, 191 Auditorium Road, U-3222, Storrs, Connecticut3

Received 31 March 2006/ Accepted 5 July 2006

Autoinducer 2 (AI-2) quorum sensing was shown before to regulate the virulence of Vibrio harveyi towards the brine shrimp Artemia franciscana. In this study, several different pathogenic V. harveyi, Vibrio campbellii, and Vibrio parahaemolyticus isolates were shown to produce AI-2. Furthermore, disruption of AI-2 quorum sensing by a natural and a synthetic brominated furanone protected gnotobiotic Artemia from the pathogenic isolates in in vivo challenge tests.

* Corresponding author. Mailing address: LabMET, Coupure Links 653, B-9000 Ghent, Belgium. Phone: 32 (0)9 264 59 76. Fax: 32 (0)9 264 62 48. E-mail: Willy.Verstraete{at}UGent.be.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

{ddagger} Present address: Department of Chemical Engineering, Texas A&M University, 3122 TAMU, College Station, TX 77843-3122.

Applied and Environmental Microbiology, September 2006, p. 6419-6423, Vol. 72, No. 9
0099-2240/06/$08.00+0     doi:10.1128/AEM.00753-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Lonn-Stensrud, J., Landin, M. A., Benneche, T., Petersen, F. C., Scheie, A. A. (2009). Furanones, potential agents for preventing Staphylococcus epidermidis biofilm infections?. J Antimicrob Chemother 63: 309-316 [Abstract] [Full Text]  
  • Janssens, J. C. A., Steenackers, H., Robijns, S., Gellens, E., Levin, J., Zhao, H., Hermans, K., De Coster, D., Verhoeven, T. L., Marchal, K., Vanderleyden, J., De Vos, D. E., De Keersmaecker, S. C. J. (2008). Brominated Furanones Inhibit Biofilm Formation by Salmonella enterica Serovar Typhimurium. Appl. Environ. Microbiol. 74: 6639-6648 [Abstract] [Full Text]  


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