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Applied and Environmental Microbiology, July 2007, p. 4668-4672, Vol. 73, No. 14
0099-2240/07/$08.00+0     doi:10.1128/AEM.02604-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Mobile Genetic Elements Provide Evidence for a Bovine Origin of Clonal Complex 17 of Streptococcus agalactiae{triangledown}

Geneviève Héry-Arnaud,1 Guillaume Bruant,1,{dagger} Philippe Lanotte,1,2 Stella Brun,1 Bertrand Picard,3 Agnès Rosenau,1 Nathalie van der Mee-Marquet,1,2 Pascal Rainard,4 Roland Quentin,1,2 and Laurent Mereghetti1,2*

Université François-Rabelais, IFR 136, Faculté de Médecine, EA 3854 Bactéries et Risque Materno-Foetal, Tours, France,1 Centre Hospitalier Universitaire, Tours, France,2 Service de Microbiologie, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris, Bobigny, France,3 Institut National de la Recherche Agronomique, UR1282, Infectiologie Animale et Santé Publique, Nouzilly, France4

Received 8 November 2006/ Accepted 12 May 2007

We sought an explanation for epidemiological changes in Streptococcus agalactiae infections by investigating the link between ecological niches of the bacterium by determining the prevalence of 11 mobile genetic elements. The prevalence of nine of these elements differed significantly according to the human or bovine origin of the isolate. Correlating this distribution with the phylogeny obtained by multilocus sequence analysis, we observed that human isolates harboring GBSi1, a clear marker of the bovine niche, clustered in clonal complex 17. Our results are thus consistent with the emergence of this virulent human clone from a bovine ancestor.

* Corresponding author. Mailing address: EA 3854 "Bactéries et Risque Materno-Foetal," Laboratoire de Bactériologie, Faculté de Médecine de Tours, Université François-Rabelais, 2 bd. Tonnellé, 37032 Tours, France. Phone: 33 247478056. Fax: 33 247473812. E-mail: laurent.mereghetti{at}med.univ-tours.fr

{triangledown} Published ahead of print on 25 May 2007.

{dagger} Present address: Groupe de Recherche sur les Maladies Infectieuses du Porc, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada.

Applied and Environmental Microbiology, July 2007, p. 4668-4672, Vol. 73, No. 14
0099-2240/07/$08.00+0     doi:10.1128/AEM.02604-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Lartigue, M.-F., Hery-Arnaud, G., Haguenoer, E., Domelier, A.-S., Schmit, P.-O., van der Mee-Marquet, N., Lanotte, P., Mereghetti, L., Kostrzewa, M., Quentin, R. (2009). Identification of Streptococcus agalactiae Isolates from Various Phylogenetic Lineages by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry. J. Clin. Microbiol. 47: 2284-2287 [Abstract] [Full Text]  


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