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Applied and Environmental Microbiology, July 2007, p. 4691-4694, Vol. 73, No. 14
0099-2240/07/$08.00+0     doi:10.1128/AEM.00496-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Alpha-Agarases Define a New Family of Glycoside Hydrolases, Distinct from Beta-Agarase Families{triangledown}

Didier Flament,{dagger} Tristan Barbeyron, Murielle Jam, Philippe Potin, Mirjam Czjzek, Bernard Kloareg, and Gurvan Michel*

Centre National de la Recherche Scientifique, Université Pierre et Marie Curie-Paris6, Unité Mixte de Recherche 7139, Station Biologique, F-29682 Roscoff Cedex, Bretagne, France

Received 5 March 2007/ Accepted 12 May 2007

The gene encoding the {alpha}-agarase from "Alteromonas agarilytica" (proposed name) has been cloned and sequenced. The gene product (154 kDa) is unrelated to ß-agarases and instead belongs to a new family of glycoside hydrolases (GH96). The {alpha}-agarase also displays a complex modularity, with the presence of five thrombospondin type 3 repeats and three carbohydrate-binding modules.

* Corresponding author. Mailing address: Centre National de la Recherche Scientifique, Université Pierre et Marie Curie-Paris6, Unité Mixte de Recherche 7139, Station Biologique, F-29682 Roscoff Cedex, Bretagne, France. Phone: 33 298 29 23 30. Fax: 33 298 29 23 24. E-mail: gurvan{at}sb-roscoff.fr

{triangledown} Published ahead of print on 18 May 2007.

{dagger} Present address: UMR 6197 (IFREMER/CNRS), Laboratoire de Microbiologie et Environnements Extremes, Plouzane, Bretagne, France.

Applied and Environmental Microbiology, July 2007, p. 4691-4694, Vol. 73, No. 14
0099-2240/07/$08.00+0     doi:10.1128/AEM.00496-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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