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Applied and Environmental Microbiology, December 2007, p. 7767-7770, Vol. 73, No. 23
0099-2240/07/$08.00+0     doi:10.1128/AEM.01477-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Intestinal Integrity and Akkermansia muciniphila, a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly{triangledown}

M. Carmen Collado,1* Muriel Derrien,2 Erika Isolauri,3 Willem M. de Vos,2,4 and Seppo Salminen1

Functional Foods Forum, University of Turku, FI-20014 Turku, Finland,1 Laboratory of Microbiology, Wageningen University, 6703 HB Wageningen, The Netherlands,2 Department of Pediatrics, University of Turku, FI-20014 Turku, Finland,3 Department of Basic Veterinary Sciences, Helsinki University, FI-00014 Helsinki, Finland4

Received 2 July 2007/ Accepted 30 September 2007

Fluorescence in situ hybridization and real-time PCR analysis targeting the 16S rRNA gene of Akkermansia muciniphila were performed to determine its presence in the human intestinal tract. These techniques revealed that an A. muciniphila-like bacterium is a common member of the human intestinal tract and that its colonization starts in early life and develops within a year to a level close to that observed in adults (108 cells/g) but decreases (P < 0.05) in the elderly.

* Corresponding author. Mailing address: Functional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, 5th floor, FI-20520 Turku, Finland. Phone: 358 2 333 6822. Fax: 358 2 333 6862. E-mail: marcol{at}utu.fi

{triangledown} Published ahead of print on 12 October 2007.

Applied and Environmental Microbiology, December 2007, p. 7767-7770, Vol. 73, No. 23
0099-2240/07/$08.00+0     doi:10.1128/AEM.01477-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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