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Applied and Environmental Microbiology, August 2008, p. 5228-5230, Vol. 74, No. 16
0099-2240/08/$08.00+0     doi:10.1128/AEM.00086-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Effect of Silver-Doped Phosphate-Based Glasses on Bacterial Biofilm Growth{triangledown}

Sabeel P. Valappil,1,2 Jonathan C. Knowles,1 and Michael Wilson2*

Division of Biomaterials and Tissue Engineering,1 Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, United Kingdom2

Received 11 January 2008/ Accepted 14 June 2008

Silver-containing phosphate-based glasses were found to reduce the growth of Pseudomonas aeruginosa and Staphylococcus aureus biofilms, which are leading causes of nosocomial infections. The rates of glass degradation (1.27 to 1.41 µg·mm–2·h–1) and the corresponding silver release were found to account for the variation in biofilm growth inhibitory effect.

* Corresponding author. Mailing address: Division of Microbial Diseases, UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, United Kingdom. Phone: 44 (0)207 915 1050. Fax: 44 (0)207 915 1127. E-mail: M.Wilson{at}eastman.ucl.ac.uk

{triangledown} Published ahead of print on 20 June 2008.

Applied and Environmental Microbiology, August 2008, p. 5228-5230, Vol. 74, No. 16
0099-2240/08/$08.00+0     doi:10.1128/AEM.00086-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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