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Applied and Environmental Microbiology, September 2008, p. 5583-5588, Vol. 74, No. 17
0099-2240/08/$08.00+0     doi:10.1128/AEM.00067-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Importance of Type II Secretion for Survival of Legionella pneumophila in Tap Water and in Amoebae at Low Temperatures{triangledown}

Maria A. Söderberg, Jenny Dao, Shawn R. Starkenburg, and Nicholas P. Cianciotto*

Department of Microbiology and Immunology, Northwestern University Medical School, Chicago, Illinois 60611

Received 9 January 2008/ Accepted 5 July 2008

Legionella pneumophila type II secretion mutants showed reduced survival in both tap water at 4 to 17°C and aquatic amoebae at 22 to 25°C. Wild-type supernatants stimulated the growth of these mutants, indicating that secreted factors promote low-temperature survival. There was a correlation between low-temperature survival and secretion function when 12 additional Legionella species were examined.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Northwestern University Medical School, 320 East Superior St., Chicago, IL 60611. Phone: (312) 503-0385. Fax: (312) 503-1339. E-mail: n-cianciotto{at}northwestern.edu

{triangledown} Published ahead of print on 11 July 2008.

Applied and Environmental Microbiology, September 2008, p. 5583-5588, Vol. 74, No. 17
0099-2240/08/$08.00+0     doi:10.1128/AEM.00067-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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  • Rossier, O., Dao, J., Cianciotto, N. P. (2009). A type II secreted RNase of Legionella pneumophila facilitates optimal intracellular infection of Hartmannella vermiformis. Microbiology 155: 882-890 [Abstract] [Full Text]  
  • Stewart, C. R., Rossier, O., Cianciotto, N. P. (2009). Surface Translocation by Legionella pneumophila: a Form of Sliding Motility That Is Dependent upon Type II Protein Secretion. J. Bacteriol. 191: 1537-1546 [Abstract] [Full Text]  


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