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Applied and Environmental Microbiology, October 2008, p. 6473-6475, Vol. 74, No. 20
0099-2240/08/$08.00+0     doi:10.1128/AEM.01590-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

ShmR Is Essential for Utilization of Heme as a Nutritional Iron Source in Sinorhizobium meliloti{triangledown}

Vanesa Amarelle,1 Mark R. O'Brian,2 and Elena Fabiano1*

Laboratorio de Ecología Microbiana, Instituto de Investigaciones Biológicas Clemente Estable, MEC, Unidad Asociada a la Facultad de Ciencias, Av. Italia 3318, Montevideo 11600, Uruguay,1 Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 142142

Received 11 July 2008/ Accepted 21 August 2008

The bacterium Sinorhizobium meliloti is able to use heme as a nutritional iron source. Here, we show that the iron-regulated shmR gene encodes an outer membrane protein required for growth on heme. Furthermore, an shmR mutant is resistant to the toxic heme analog gallium protoporphyrin. Thus, the receptor protein of the heme transport system has been identified in S. meliloti.

* Corresponding author. Mailing address: Laboratorio de Ecología Microbiana, IIBCE, Av. Italia 3318, Montevideo 11600, Uruguay. Phone: 598 (2) 4871616, ext. 146. Fax: 598 (2) 4875548. E-mail: efabiano{at}iibce.edu.uy

{triangledown} Published ahead of print on 29 August 2008.

Applied and Environmental Microbiology, October 2008, p. 6473-6475, Vol. 74, No. 20
0099-2240/08/$08.00+0     doi:10.1128/AEM.01590-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gurich, N., Gonzalez, J. E. (2009). Role of Quorum Sensing in Sinorhizobium meliloti-Alfalfa Symbiosis. J. Bacteriol. 191: 4372-4382 [Abstract] [Full Text]  


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