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Applied and Environmental Microbiology, March 2008, p. 1634-1638, Vol. 74, No. 5
0099-2240/08/$08.00+0     doi:10.1128/AEM.02512-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

A Legionella pneumophila Peptidyl-Prolyl cis-trans Isomerase Present in Culture Supernatants Is Necessary for Optimal Growth at Low Temperatures{triangledown}

Maria A. Söderberg and Nicholas P. Cianciotto*

Department of Microbiology and Immunology, Northwestern University Medical School, Chicago, Illinois 60611

Received 7 November 2007/ Accepted 21 December 2007

Several Legionella pneumophila proteins were highly expressed in low-temperature supernatants. One of these proteins was the peptidyl-prolyl isomerase PpiB. Mutants lacking ppiB exhibited reduced growth at 17°C. Since PpiB lacked a signal sequence and was present in 17°C supernatants of type II and type IV secretion mutants, this protein may be secreted by a novel mechanism.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Northwestern University Medical School, 320 East Superior St., Chicago, IL 60611. Phone: (312) 503-0385. Fax: (312) 503-1339. E-mail: n-cianciotto{at}northwestern.edu

{triangledown} Published ahead of print on 28 December 2007.

Applied and Environmental Microbiology, March 2008, p. 1634-1638, Vol. 74, No. 5
0099-2240/08/$08.00+0     doi:10.1128/AEM.02512-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Rossier, O., Dao, J., Cianciotto, N. P. (2009). A type II secreted RNase of Legionella pneumophila facilitates optimal intracellular infection of Hartmannella vermiformis. Microbiology 155: 882-890 [Abstract] [Full Text]  
  • Stewart, C. R., Rossier, O., Cianciotto, N. P. (2009). Surface Translocation by Legionella pneumophila: a Form of Sliding Motility That Is Dependent upon Type II Protein Secretion. J. Bacteriol. 191: 1537-1546 [Abstract] [Full Text]  
  • Soderberg, M. A., Dao, J., Starkenburg, S. R., Cianciotto, N. P. (2008). Importance of Type II Secretion for Survival of Legionella pneumophila in Tap Water and in Amoebae at Low Temperatures. Appl. Environ. Microbiol. 74: 5583-5588 [Abstract] [Full Text]  


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