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Applied and Environmental Microbiology, May 2009, p. 3373-3376, Vol. 75, No. 10
0099-2240/09/$08.00+0     doi:10.1128/AEM.00207-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

The Virulent Wolbachia Strain wMelPop Efficiently Establishes Somatic Infections in the Malaria Vector Anopheles gambiae{triangledown}

Chaoyang Jin ,1,§,{dagger} Xiaoxia Ren,1,2,{dagger} and Jason L. Rasgon1,2*

The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205,1 The Johns Hopkins Malaria Research Institute, Baltimore, Maryland 212052

Received 29 January 2009/ Accepted 20 March 2009

Wolbachia pipientis bacteria are maternally inherited endosymbionts that are of interest to control the Anopheles mosquito vectors of malaria. Wolbachia does not infect Anopheles mosquitoes in nature, although cultured Anopheles cells can be infected. Here, we show that the virulent Wolbachia strain wMelPop can survive and replicate when injected into female Anopheles gambiae adults, but the somatic infections established are avirulent. These in vivo data suggest that stable Wolbachia infections of Anopheles may be possible.

* Corresponding author. Mailing address: The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, E4626, 615 N. Wolfe Street, Baltimore, MD 21205. Phone: (410) 502-2584. Fax: (410) 955-0105. E-mail: jrasgon{at}jhsph.edu

{triangledown} Published ahead of print on 27 March 2009.

§ Present address: Canada's Michael Smith Genome Sciences Centre, Vancouver, Canada.

{dagger} C.J. and X.R. contributed equally to this work.

Applied and Environmental Microbiology, May 2009, p. 3373-3376, Vol. 75, No. 10
0099-2240/09/$08.00+0     doi:10.1128/AEM.00207-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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