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Applied and Environmental Microbiology, January 2009, p. 538-541, Vol. 75, No. 2
0099-2240/09/$08.00+0     doi:10.1128/AEM.01827-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Lacticin Q, a Lactococcal Bacteriocin, Causes High-Level Membrane Permeability in the Absence of Specific Receptors{triangledown}

Fuminori Yoneyama,1 Yuichi Imura,3 Shiro Ichimasa,1 Koji Fujita,1 Takeshi Zendo,1 Jiro Nakayama,1 Katsumi Matsuzaki,3 and Kenji Sonomoto1,2*

Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School,1 Laboratory of Functional Food Design, Department of Functional Metabolic Design, Bio-Architecture Center, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan,2 Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimo-adachi-cho, Sakyo-ku, Kyoto 606-8501, Japan3

Received 7 August 2008/ Accepted 10 November 2008

To characterize the mode of action of lacticin Q (LnqQ), its membrane-permeabilizing activity was compared with that of nisin A because of the similar antimicrobial features of these compounds. Lipid II, the receptor for nisin A, was not required for LnqQ activity. LnqQ induced high-level membrane permeability in the absence of specific receptors.

* Corresponding author. Mailing address: Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. Phone and fax: (81) 92 642 3019. E-mail: sonomoto{at}agr.kyushu-u.ac.jp

{triangledown} Published ahead of print on 14 November 2008.

Applied and Environmental Microbiology, January 2009, p. 538-541, Vol. 75, No. 2
0099-2240/09/$08.00+0     doi:10.1128/AEM.01827-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Yoneyama, F., Imura, Y., Ohno, K., Zendo, T., Nakayama, J., Matsuzaki, K., Sonomoto, K. (2009). Peptide-Lipid Huge Toroidal Pore, a New Antimicrobial Mechanism Mediated by a Lactococcal Bacteriocin, Lacticin Q. Antimicrob. Agents Chemother. 53: 3211-3217 [Abstract] [Full Text]  


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